The global desalting and buffer exchange market was valued at USD 1.11 billion in 2023 and is projected to reach USD 2.18 billion by 2030, growing at a compound annual growth rate (CAGR) of 10.2% from 2024 to 2030. Market expansion is being driven by the increasing demand for efficient bioprocessing techniques across the pharmaceutical and biotechnology industries, where purity and precision in sample preparation are crucial.

Desalting and buffer exchange processes are integral steps in downstream processing, ensuring the removal of impurities, salts, and contaminants while enabling the replacement of buffers to create optimal conditions for biological samples. These processes are essential in maintaining the integrity of proteins, enzymes, monoclonal antibodies, and other biologics, which require high-purity environments for both research and therapeutic applications. With the rising production of monoclonal antibodies and the development of novel biopharmaceuticals, the adoption of desalting and buffer exchange methods has become increasingly widespread.

The market is further supported by the expansion of the global bioprocessing sector, particularly in emerging economies where investments in biotechnology research, biologics production, and advanced healthcare infrastructure are accelerating. Additionally, the shift toward personalized medicine is creating greater demand for efficient sample preparation and purification methods, since therapies tailored to individual patient needs require a higher level of precision and reliability.

Another significant factor fueling growth is the integration of advanced technologies into life sciences and healthcare. Breakthroughs in genomics, biotechnology, and artificial intelligence (AI) have reduced the cost and complexity of sequencing and analyzing health data, making it easier to design and deliver personalized treatments. This trend emphasizes the critical role desalting and buffer exchange techniques play in supporting high-throughput workflows and maintaining the quality of sensitive biological materials.

Key Market Trends & Insights:

• Regional Insights: In 2023, the Asia Pacific region dominated the market with a 37.7% revenue share, supported by significant investments in biotechnology research, the rapid expansion of pharmaceutical manufacturing, and government initiatives to strengthen bioprocessing infrastructure. This region is expected to remain a focal point for growth as demand for biologics continues to rise.
• By Product: The cassette & cartridges segment led the market in 2023, accounting for 24.1% of global revenue share, owing to their wide adoption in laboratories and biopharmaceutical production for their ease of use and scalability. Meanwhile, the membrane filter segment is anticipated to grow at a notable CAGR of 10.8% during the forecast period, as membrane technologies gain traction for their efficiency, cost-effectiveness, and compatibility with single-use systems.
• By Technique: The filtration segment dominated in 2023, with a 43.7% revenue share, reflecting its widespread use in desalting and buffer exchange workflows for protein purification and sample preparation. The chromatography segment is forecasted to grow at 10.4% CAGR over the forecast period, driven by its precision in separating and purifying complex biomolecules in biopharmaceutical production.
• By Application: The bioprocessing application segment accounted for 37.5% of the global revenue share in 2023, underscoring its critical role in manufacturing biologics, vaccines, and therapeutic proteins. Meanwhile, the diagnostic application segment is expected to grow significantly at a CAGR of 10.7% from 2024 to 2030, fueled by rising demand for accurate and efficient sample preparation in clinical diagnostics and research.

Order a free sample PDF of the Desalting And Buffer Exchange Market Intelligence Study, published by Grand View Research.

Market Size & Forecast:

• 2023 Market Size: USD 1.11 Billion
• 2030 Projected Market Size: USD 2.18 Billion
• CAGR (2024-2030): 10.2%
• Asia Pacific: Largest market in 2023

Key Companies & Market Share Insights:

The desalting and buffer exchange market features a mix of established global leaders and emerging players, all competing to expand their product portfolios and market presence. Some of the leading companies include GE Healthcare, Thermo Fisher Scientific, and Danaher, along with growing participants such as Biotage, Sartorius, Avantor Inc., and PhyNexus Inc.

• GE Healthcare: A leading provider of desalting and buffer exchange technologies, GE Healthcare offers a wide range of solutions tailored to bioprocessing applications. Its focus on continuous innovation, quality, and customer service has cemented its strong position in the market.
• Thermo Fisher Scientific: As a global leader in biotechnology solutions, Thermo Fisher provides an extensive portfolio of desalting and buffer exchange products. Its offerings span across industries including pharmaceuticals, biotechnology, academia, government, and environmental sectors. The company is recognized for its comprehensive solutions that support research, analysis, discovery, and diagnostics.
• Sartorius AG: Sartorius specializes in membrane filtration systems, with an emphasis on single-use technologies and scalability. Its solutions are widely used in bioprocessing for desalting and buffer exchange, making it a key player in this growing sector.
• Biotage: Focused on purification technologies, Biotage offers products and services that cater to the chemistry, pharmaceuticals, and biotechnology industries. Its expertise in purification makes it a valuable contributor to desalting and buffer exchange workflows, supporting scientists in the development of new therapies and advanced research.

Other companies, such as Avantor Inc. and PhyNexus Inc., are emerging as important participants, contributing to the competitive landscape by offering innovative and cost-effective solutions.

Explore our latest blogs: Global Industry Herald

Conclusion:

The global desalting and buffer exchange market is experiencing strong growth, driven by rising demand for biologics, increasing monoclonal antibody production, and the need for efficient downstream processing solutions. With Asia Pacific leading in revenue share and poised for rapid expansion, the market is expected to continue evolving alongside advances in biotechnology and personalized medicine. Established players like GE Healthcare and Thermo Fisher Scientific, along with innovative companies such as Sartorius and Biotage, will play key roles in shaping the future of the industry through product innovation, scalability, and technological advancement.